1. 제 목 : Wound Monitor
2. 발 표 자 : Professor Krishna Persaud (Manchester University, UK)
3. 일 시 : 2008년 8월 7일(목) 오전 10:00~12:00
4. 장 소 : 공대5호관 104호
5. 초청교수 : 이덕동, 함성호(경북대 전자전기컴퓨터학부), 허증수(신소재공학부),
6. 강사약력
1980 MS / 1985 Ph.D
In UK, he is recruited to be a Professor from 1986.
Now he is director of Research Institute of Instrumentation and Analytical Science.
He is a Pioneer in Electronic Nose Field.
Professor Krishna C. Persaud FRSC, FInstMC, is Professor of Chemoreception in the School of Chemical Engineering
and Analytical Science, The University of Manchester, and director of the Olfactory Research Group. Experience and
background: Synthesis of heterocyclic materials, Conducting polymer gas sensors, Array-based chemical sensors, Odour
sensing, Artificial neural networks, Chemometrics, Physicochemical mechanisms of gas adsorption, Biological aspects of
olfaction sensory physiology, brain function. More than 180 publications in the field.
7. 내용요약
Smell used to be a common diagnostic tool in medicine, and physicians were trained to use their sense of smell during their medical training. Latterly, odour diagnostics have been relegated to secondary status as a diagnostic method. Array based gas sensor technology now offers the potential of a robust analytical approach to odour measurement for medical use. Wounds are injuries to body tissues caused by diseases processes or events such as burns, punctures, chronic leg or decubitus ulcers- and results of surgery. Wounds become infected when microorganisms from the environment or from the patient''''s body enter the open wound and multiply. The symptoms related to an infection include abnormal flushing of the skin, heat, pain and tenderness and abnormal odours, such as fruity odours that often indicate the presence of Staphylococcus or foul odours due to presence of gram negative bacteria. Standard techniques for microbiological detection are surface swabbing and wound biopsy culture. Surface swabbing is the most used technique mainly because is quite inexpensive and is not invasive but can give only a representation of the surface infected and is time consuming. Biopsies are invasive and are inconvenient.
We are developing a fast reliable method for detection of microbial infection by monitoring the headspace from the infected wounds funded via an IST-027859 EU project WOUNDMONITOR. In this paper we present results obtained by analysing the headspace volatiles emitted from Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa in order to identify volatile markers of infection. The results obtained from this GC-MS study are enabling us to build a mobile system for non invasive wound monitoring using an array of gas and odour sensors, to be used for point of care monitoring of patients. Sensors based on metal oxide and conductive polymer films were produced and modified and refined aiming to detect the most probable key markers for the bacteria types that is described as most frequently found in clinical conditions. The criteria for selection of the sensors was determined by the sensitivity and selectivity of the sensors to a limited number of the volatile compounds (VOC) produced by living bacteria types that are defined as the most frequently found in clinical conditions during treatment of limited types of wounds.
For sampling from swabs or dressings from patients a solid phase microextraction approach was used for preconcentration of the low concentrations of volatile compounds emitted. An instrument was constructed that incorporated an automated solid phase microextraction desorption system, a hybrid sensor array, electronics, and data processing to enable the system to be used for clinical validation.
The instrument is being validated over the next year in two hospitals where patients with serious burns are treated.
※ 주최 : 센서기술연구소(STRC), BK21 정보기술연구인력양성사업단, 반도체공정교육 및 지원센터(NECST)
■ 문의처 : 반도체공정교육 및 지원센터(NECST) ☎ 053-950-7591 ■
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