1. 제 목 : Two Types of Novel Optical Nano-Constructs Composed of Biomaterials Doped with a Near Infrared Dye

2. 발 표 자 : Bongsu Jung, Ph.D.

3. 일 시 : 2011년 10월 10일(월) 16:00 ~ 17:00 

4. 장 소 : IT대학 2호관 104호 

5. 초청교수 : 김지현 교수 

6. 강사약력 :

(학 력)

1991 ~ 1997 연세 대학교 의공학 공학사

2003 ~ 2005 University fo Texas at Austin, 의공학 공학석사

2005 ~ 2007 University fo Texas at Austin, 의공학 공학박사

(경 력)

1997 ~ 2001 GE Healthcare Korea 연구소 연구원

2008 ~ 현재 University of California Riverside, 박사 후 연구원

7. 내용요약 :  

In this presentation, I will present two types of novel optical nano-constructs composed of biomaterials doped with a near infrared dye.

1) We have engineered an optical nanoconstruct composed of genome-depleted Brome Mosaic Virus(BMV) doped with indocyanine green (ICG), an FDA-approved near-infrared (NIR) chromophore. Constructs are highly monodispersed with standard deviation of ±3.8 nm from a mean diameter of 24.3 nm.They are physically stable and exhibit a high degree of optical stability at physiological temperature (37 °C). Using human bronchial epithelial cells, we demonstrate the effectiveness of the constructs for intracellular optical imaging in vitro, with greater than 90% cell viability after 3 h of incubation. These constructs may serve as a potentially nontoxic and multifunctional nanoplatform for site-specific deep-tissue optical imaging, and therapy of disease.

2). Bovine Serum Albumin (BSA) is biocompatible and versatile protein for surface conjugation with various materials. We have synthesized and characterized BSA-coated nanocapsules loaded with ICG (BSA-ICG NCs) as potential multi-functional nano-constructs. To the best of our knowledge, the present study is the first to report successful fabrication of nanocapsule doped with ICG, an FDA-approved NIR dye, and surface-conjugated with BSA.

In this study, BSA-ICG NCs were used for in-vitro cellular imaging with normal human endocervical epithelial cells.As a multi-platform system, BSA-ICG NCs can be potentially used for drug/gene delivery, in-vivo cellular monitoring, and phototherapy in the future application,.

※ 주최 : BK21 정보기술연구인력양성사업단, IT대학

◀ 문의처 : BK21정보기술연구인력양성사업단 ☎ 950-6613 ▶